Mild atypical breast cells

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This study analyzes the interobserver variability in interpreting atypia on breast core needle biopsies and in each category of atypia calculates the upgrade risk of carcinoma in the subsequent surgical excision. We identified 51 cases of atypia on breast core needle biopsies performed at our institution from January to August After a tutorial session, these cases were independently reviewed by four pathologists, whose overall multi-rater kappa value for agreement on different categories of atypia was 0.

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In order for cells removed during a biopsy to be examined, they must be put on a slide, stained, and then looked at under a microscope. Cells are judged based on a number of criteria, including the size and color of the nucleus the center of the cell that contains DNAthe appearance of the other structures in the cytoplasm the area between the nucleus and the outer wall of the celland the overall size of the cell itself. For centuries, pathologists physicians who identify diseases by studying cells and tissues under a microscope have been trying to predict how cells will behave based on how they appear.

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What is hyperplasia? Treatment and follow-up 6. What this means for you.

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Atypical ductal hyperplasia ADH is not a form of breast cancer. Rather, it is a marker for women who may have a risk factor for developing breast cancer in the future. If you have a biopsy that shows atypical ductal hyperplasia in one of your breasts, your doctor will want to follow your breast health very carefully. Armed with this knowledge, you will want to choose a comprehensive breast center.

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Atypical ductal hyperplasia ADH is a common diagnosis in the mammographic era and a significant clinical problem with wide variation in diagnosis and treatment. After a diagnosis of ADH on biopsy a proportion are upgraded to carcinoma upon excision; however, the remainder of patients are overtreated. While ADH is considered a non-obligate precursor of invasive carcinoma, the molecular taxonomy remains unknown.

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Questions come to your mind such as: What does this mean? Do I need surgery? How does this affect my breast cancer risk?

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Atypical ductal hyperplasia ADH is when a breast has more than the normal two layers of cells in the milk ducts and those additional cells are abnormal in size, shape, appearance, and growth pattern. Atypical ductal hyperplasia is diagnosed with a biopsy; it cannot be detected via a breast exam or imaging. If found, atypical ductal hyperplasia will require close monitoring.

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When your breast was biopsied, the samples taken were studied under the microscope by a specialized doctor with many years of training called a pathologist. The pathologist sends your doctor a report that gives a diagnosis for each sample taken. Information in this report will be used to help manage your care. The questions and answers that follow are meant to help you understand medical language you might find in the pathology report from a breast biopsysuch as a needle biopsy or an excision biopsy.

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Subscribe to our What's New in Pathology newsletter - next issue on Hematopathology coming out soon. Jorns, M. Page views in 14,

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Ductal breast cancer is thought to begin with abnormal tissue growth in a breast duct. Normal breast duct is shown. An overgrowth of normal cells may develop in the breast duct hyperplasia.

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